Multidrug resistance pattern of Staphylococcus aureus isolated from human clinical samples in different age and sex groups in Mirpur area, Dhaka City, Bangladesh

Abstract

There is a high degree of antibiotic resistance, which poses a regional and global threat. Mortality and economic burden have increased worldwide due to antibiotic resistance. Bangladesh is a developing country in Southeast Asia and facing challenges of multi-drug resistance. Staphylococcus aureus is an important human pathogen that causes skin and soft tissue infection, especially abscess formation. The present study was conducted to find out the multi-drug resistance pattern of isolated Staphylococcus aureus from pus samples. A prospective study was carried out at Mirpur, Dhaka, Bangladesh, and 80 samples were collected by using the purposive sampling technique. The antibiotic susceptibility of the S. aureus isolates was determined using the standard disc-diffusion (Kirby-Bauer) method. Antibiotics Amoxicillin + Clavulanic acid (Amo+CA), Co-trimoxazole (COT), Doxycycline (DO), Azithromycin (AZM), Cefixime (CFX), Ceftriaxone (CTR), Ciprofloxacin (CIP), Nalidixic acid (NA), Gentamycin (GEN), Chloramphenicol (C), Nitrofurantoin (NIT), Meconium (MEC), Levofloxacin (LEVO) and Meropenem (MEM) were used for the study. It was seen that 0 % (Cefixime) to 82.5% (Mecilinam) of S. aureus is resistant to the antibiotics used against them. Ceftriaxone (96.25% sensitive) is the best drug for the treatment of S. aureus infection followed by meropenem (95 % sensitive). Due to some limitations, it could not become to a concrete conclusion. It is necessary to conduct further large-scale studies considering the present study scenario